Marco Alifano

Chef de service de chirurgie thoracique, Hôpital Cochin

Titres & diplômes

  • Professeur des Universités-Praticien Hospitalier (PU-PH) (2011)
  • Membre, Collège Français de Chirurgie Thoracique et Cardiovasculaire (2009)
  • Titulaire d’une Habilitation à Diriger des Recherches, Université Paris V (2009)
  • Thèse de Science en physiologie et physiopathologie, Université Paris VI (2009)
  • Master II en Biologie et thérapies innovantes de grandes fonctions, spécialité Sciences chirurgicales, option Cancérologie, Université Paris XI (2006)
  • Chirurgien des Hôpitaux (2005)
  • Ancien Chef de Clinique à la Faculté, Ancien Assistant des Hôpitaux de Paris (2002)
  • Spécialiste en Chirurgie Thoracique, Université de Naples, Italie (1997)
  • Docteur en Médecine, Université de Naples, Italie (1992)

Fonction actuelle

  • Chef de service de chirurgie thoracique, Hôpital Cochin
  • PU-PH, Adjoint au Chef de Service, Service de Chirurgie Thoracique, Hôpitaux Universitaires Paris Centre, Paris

Publications (PubMed)

Articles originaux dans journaux à comité de lecture international

  • Fournel L, Etienne H, Mansuet Lupo A, Damotte D, Rouquette A, Revel MP, Guinet C, Alifano M, Regnard JF. Correlation between radiological and pathological features of operated ground glass nodules. Eur J Cardiothorac Surg. 2017; 51:248–254
  • Hervochon R, Bobbio A, Guinet C, Mansuet-Lupo A, Rabbat A, Régnard JF, Roche N, Damotte D, Iannelli A, Alifano M. Body Mass Index and Total Psoas Area Affect Outcomes in Patients Undergoing Pneumonectomy for Cancer. Ann Thorac Surg. 2017 Jan;103(1):287-295
  • Alifano M, Jayle C, Bertin F, Magdeleinat P, Castier Y, Tiffet O, Bernard A, Tronc F, Brichon PY, Dumont P, Grosdidier G, Dujon A, Grine A, Pereira H, Le Jeannic A, Vinet MA, MaOulida H, Durand-Zaleski I, Riquet M, Chatellier G, Regnard JF on behalf of the FORESEAL Investigators. Medical and economic evaluation of FOREseal® bioabsorbable reinforcement sleeves compared to current standard of care for reducing air leakage duration after lung resection for malignancy: a randomized trial. Ann Surg, Ann Surg. 2017 Jan;265(1):45-53
  • Frija-Masson J, Martin C, Regard L, Lothe MN, Touqui L, Durand A, Lucas B, Damotte D , Alifano M, Fajac I, Burgel PR. Bacteria-driven peribronchial lymphoid neogenesis in bronchiectasis and cystic fibrosis. Eur Respir J. 2017 Apr 26;49(4). pii: 1601873
  • Cusumano G, Fournel L, Strano S, Damotte D, Charpentier MC, Galia A, Terminella A, Nicolosi M, Regnard JF, Alifano M. Surgical Resection for Pulmonary Carcinoid: Long-Term Results of Multicentric Study-The Importance of Pathological N Status, More Than We Thought. Lung. 2017 Dec;195(6):789-798. doi: 10.1007/s00408-017-0056-8
  • Bobbio A, Canny E, Mansuet Lupo A, Lococo F, Legras A, Magdeleinat P, Regnard JF, Gompel A, Damotte D, Alifano M. Thoracic Endometriosis Syndrome Other Than Pneumothorax: Clinical and Pathological Findings. Ann Thorac Surg. 2017 Dec;104(6):1865-1871
  • Lococo F, Torricelli F, Rossi G, Alifano M, Damotte D, Rapicetta C, Tamagnini I, Cavazza A, Piana S, Galeone C, Paci M, Ciarrocchi A. Inter-relationship between PD-L1 expression and clinic-pathological features and driver gene mutations in pulmonary sarcomatoid carcinomas. Lung Cancer. 2017 Nov;113:93-101
  • Fournel L, Maria S, Seminel M, Nesci J, Mansuet-Lupo A, Guinet C, Magdeleinat P, Bobbio A, Regnard JF, Alifano M. Prognostic factors after pulmonary metastasectomy of colorectal cancers: a single-center experience. J Thorac Dis. 2017 Oct;9(Suppl 12):S1259-S1266. doi: 10.21037/jtd.2017.04.44
  • Peranzoni E, Bougherara H, Barrin S, Mansuet-Lupo A, Alifano M, Damotte D, Donnadieu E.  Ex Vivo Imaging of Resident CD8 T Lymphocytes in Human Lung Tumor Slices Using Confocal Microscopy. J Vis Exp. 2017 Dec 27;(130). doi: 10.3791/55709
  • Saidu NEB,  Bretagne M,  Lupo Mansuet A, Just PA, Leroy K, Cerles O, Chouzenoux S, Nicco C, Damotte D, Alifano M, Borghese B, Goldwasser F, Batteux F, Alexandre J. Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells.  Oncotarget. 2018; 9:9088-9099.
  • Braud VM, Biton J, Becht E, Knockaert S, Mansuet-Lupo A, Cosson E, Damotte D, Alifano M, Validire P, Anjuère F, Cremer I, Girard N, Gossot D, Seguin-Givelet A, Dieu-Nosjean MC, Germain C. Expression of LLT1 and its receptor CD161 in lung cancer is associated with better clinical outcome. Oncoimmunology, in press

Articles de synthèse & revues bibliographiques dans journaux à comité de lecture international

  • Alifano M, Benedetti G, Trisolini R. Can low-molecular weight heparins improve the outcome of  non-small cell lung cancer undergoing surgery? An urgent call for research. Chest  2004;126:601-7
  • Alifano M, Trisolini R, Cancellieri A, Régnard JF. Thoracic endometriosis. A review of current knowledge. Ann Thorac Surg, 2006;81:761-9                                       
  • Boaron M, Kawamukai, K, Forti Parri S, Alifano M, Trisolini R. Surgical procedures in mediastinal lung cancer staging. Ann Oncol. 2006;17 S2:22-23        
  • Alifano M, Courdec LJ, Cuvelier A, Delage A, Devillier P, Lamia B, Marquette CH, Molano LC, Roche N. Treatment of COPD: from pharmacological to instrumental therapies. Eur Respir Rev 2010; 19: 7-23
  • Alifano M. Catamenial Pneumothorax. Curr Opin Pulm Med 2010; 16:381-6.    
  • S. Dupouy, N Mourra, VK Doan, A Gompel, Alifano M, P Forgez The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers. Biochimie 2011;93(9):1369-78
  • Bobbio A, Trisolini R, Damotte D, Alifano M. Thoracic endometriosis and catamenial pneumothorax. Eur Respir Monograph, 2011; 54 (Orphan Lung Diseases): 265-281
  • Lococo F, Cesario A, Paci M, Filice A, Versari A, Rapicetta C, Ricchetti T, Sgarbi G, Alifano M, Cavazza A, Treglia G. PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids. Tumour Biol. 2014 Sep;35(9):8369-77

Editoriaux sur invitation dans journaux à comité de lecture international

  • Alifano M, Regnard JF. Postoperative pneumonia in lung cancer patients: chronic obstructive pulmonary disease, pre-operative bronchial colonization and antibioprophylaxis are critical issues. Eur J Cardiothorac Surg 2010;37:750-1
  • Alifano M, Damotte D. Prognostic value of LIPC in non-small cell lung carcinoma. Cell Cycle. 2013 Jan 31;12(4):2-3
  • Alifano M. Invited commentary. Ann Thorac Surg. 2013 Oct;96(4):1208. doi: 10.1016/j.athoracsur.2013.06.006.
  • Bobbio A, Alifano M. Immune therapy of non-small cell lung cancer. The future. Pharmacol Res. 2015 Sep;99:217-22
  • Lococo F, Cusumano G, Margaritora S,  Alifano M, Leuzzi G, Paci M. Sleeve lobectomy or pneumonectomy for non-small cell lung cancer? Searching for an optimal balance between oncological, surgical and functional results.  Translational Cancer Research 2016;5(suppl 6): S1102-S1106

Lettres à l’Editeur dans journaux à comité de lecture international

  • Venissac N, Alifano M, Dahan M, Mouroux J. Intrathoracic migration of Kirschner pins: is video-assisted thoracic surgery justified? (Reply) Ann Thorac Surg 2001;72:669
  • Mulot A, Sepulveda S, Haberer JP, Alifano M,. Diagnosis of postpneumonectomy bronchopleural fistula using inhalation of oxygen and nitrous oxide. Anesth Analg 2002;95:1122-3
  • Roth T, Alifano M, Magdeleinat P, Schussler O, Régnard JF A Suggestion Regarding Catamenial Pneumothorax (Reply). Ann Thorac Surg 2003;75:1684-84
  • Alifano M, Magdeleinat P, Régnard JF. Catamenial pneumothorax: some commentaries (letter). J Thorac Cardiovasc Surg 2005;129:1199
  • Alifano M, Benedetti G, Trisolini R. Low-Molecular-weight heparin and outcomes (Reply). Chest, 2005;128:471-2
  • Schussler O, Dermine H, Alifano M, Casetta A, Coignard S, Roche N,  Strano S, , Meunier A, Salvi M, Magdeleinat P, Rabbat A, Régnard JF. Antibiotic prophylaxis for lung surgery: bronchial colonization is the critical issue? (Reply) Ann Thorac Surg. 2009;88:1051-2
  • Alifano M. Pleural endometriosis and recurrent pneumothorax: the role of magnetic resonance imaging (reply). Ann Thorac Surg 2012; 93: 697 – 698
  • Baud M, Forgez P, Damotte D, Alifano M. The dog did not bark. Reply to the editor. J Thorac Cardiovasc Surg. 2013 Oct;146(4):990-1. doi: 10.1016/j.jtcvs.2013.05.02
  • Strano S, Damotte D, Alifano M. Immunohistochemical Improvement in the Analysis of the Lymphatic Metastases From Lung Carcinoma. Reply. Ann Thorac Surg 2014;97:381-3

"Case reports" dans journaux à comité de lecture international

  • Alifano M, Veyrie N, Rabbat A. Pneumothorax, pneumomediastinum and hemorrhagic shock complicating oxygen administration through a nasopharyngeal catheter. Ann Thorac Surg 2010;90:2061
  • Legras A, Guinet C, Alifano M, Lepilliez A, Régnard JF. A case of variant scimitar syndrome. Chest. 2012 Oct;142(4):1039-41
  • Lococo F, Charpentier MC, Brandolini J, Hamelin-Canny E, Alifano M.  Liposarcoma of the right thoracic inlet with intravascular extension and fatly thrombus into the right brachiocephalic vein. Ann Thorac Surg. 2013 May;95(5):e129. doi: 10.1016/j.athoracsur.2012.10.053
  • S Challita, M Daher, N Roche, M Alifano, MP Revel, A Rabbat. Pneumorachis after cocaine sniffing.  Respiratory medicine case reports 2014 ; 12 :10-12
  • Lococo F, Charpentier MC, Guinet C, Brandolini J, Alifano M, Regnard JF. Mediastinal recurrence from ovarian cystadenocarcinoma presenting as pleuro-pericardial cyst. Eur Rev Med Pharmacol Sci. 2014;18(15):2094-6
  • Bobbio A, Hamelin-Canny E, Roche N, Taillia H, Alifano M.Abducens nerve palsy after schwannoma resection. Ann Thorac Surg. 2015 Feb;99(2):694-5
  • Gaucher S, Bobbio A, Mansuet-Lupo A, Hamelin-Canny E, Hautier A, Nicolas C, Alifano M. Late costal osteomyelitis with a cutaneous fistula after flame burns: a case report J Wound Care. 2016 Feb;25(2):104-7
  • Paepegaey AC, Cochand-Priollet B, Louiset E, Sarfati PO, Alifano M, Burnichon N, Bienvenu-Perrard M, Lahlou N, Bricaire L, Groussin L. Long-Term Control of Hypercortisolism by Vandetanib in a Case of Medullary Thyroid Carcinoma with a Somatic RET Mutation. Thyroid. 2017 Apr;27(4):587-590
  • Canouï E, Blanc K, Loubinoux J, Valade S, Hamard C, Lefebvre A, Amorim S, Bébéar C, Rodriguez-Nava V, Lebeaux D, Launay O, Alifano M, Rabbat A, Kernéis S. The value of molecular techniques to diagnose Ureaplasma urealyticum and Nocardia farcinica pleuropneumonia in a patient with diffuse large B-cell lymphoma. Int J Infect Dis. 2017 Nov;64:93-95. doi: 10.1016/j.ijid.2017.09.015


  • Membre, Editorial Board, Shanghai Chest Journal
  • Membre, Commission des Effectifs, Hôpitaux Universitaires Paris Centre
  • Membre, Commission des Effectifs, APHP.5
  • Membre, Commission VAE de Cancérologie (Représentant du Conseil National de l’Ordre des Médecins)
  • Président, Commission chargée de la Procédure d’autorisation d’exercice: épreuves de vérification des connaissances – CNG (2017)
  • Membre, Groupe d’experts "Trachéotomie" COMEDIM –APHP (2007 - 2008 et 2015)
  • Membre, Groupe de travail sur la révision des structures médicales du G.H. Cochin-Hôtel-Dieu (2010)
  • Membre, Commission Structures et Projet médical (Vice-président), Hôpitaux Universitaires Paris Centre
  • Membre, Commission Structures et Projet médical APHP.5 (2018)